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KMID : 0351219940260020165
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Korean Journal of Infectious Diseases
1994 Volume.26 No. 2 p.165 ~ p.170
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Imlpenem/Cilastatin(Tienam) Monotherapy in Fegrile Granulocytopenic Patients
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박지훈
최환석/김정백/김정희/김시영/윤휘중/조경삼
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Abstract
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The need for prompt antibiotic therapy in the management of febrile neutropenic patients is well established. Imipenem is the first representitive of the new thienamycin class of antibiotics. It has the broadest antibaterial activity of all
antibiotics
available for systemic use in humans.
We performed clinical studies to assess the efficacy and tolerability of Imipenem/Cilastatin as monotherapy in 20 febrile neutropenic patients.
Clinical response rate was 80%(16/20). Microbiologically documented infections account for 55%(11/12). Microbiologic response rate was 86%(6/7) for G(+) and 75%(3/4) for G(-) infection. No serious side effects were noted in any patients.
In conclusion, Imipenem/Cilastatin is a safe and effective antibiotics as monotherapy in febrile granulocytopenic patients.
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KEYWORD
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